Heatmaps of gene exchange experiment

Credits

• Analysis by Chrispin Chaguza
• Experiments by Anna York
• Sequencing by Jason Rosch and colleagues (St Jude’s)
• Interactive plots by Dan Weinberger

Summary

These plots represent pangenomes created based on the sequenced strains. The heatmaps indicate whether a particular strain has gained a gene (yellow) or lost a gene(dark blue) compared to the reference. The plots at the bottom show the genomic location of genes gained and lost, mapped to a TIGR4 reference

Serotype 9V background

Parent strain is Serotype 9V ID ABC010001831, obtained from the CDC

Serotype 15B/C background

Parent strain is 15B/C, a carriage isolate from Hungary, ID Pool_hung_H10 (H124)

Serotype 22F background

Parent strain is serotype 22F, ID: ABC010003966, obtained from the CDC (IPD isolate)

Genomic context of gain/loss based on mapping to TIGR4 genome

Set 1

Set 2

Set 3